Question 1

Can I stop my other diabetes medications?

Accepted Answer

Never stop medications without your doctor's guidance. Many people reduce or eliminate sulfonylureas and insulin over time, but this must be done gradually with monitoring. Metformin is usually continued alongside GLP-1 therapy.

Question 2

How much will my A1C drop?

Accepted Answer

Typically 1-2 percentage points over 3-6 months, depending on your starting level and which GLP-1 you take. Tirzepatide tends to produce the largest reductions. People starting with higher A1C levels often see the biggest drops.

Question 3

Will insurance cover a GLP-1 for my diabetes?

Accepted Answer

Almost always yes. Ozempic, Mounjaro, and Trulicity are FDA-approved for type 2 diabetes. Coverage is significantly better with a T2D diagnosis than for weight loss alone. Prior authorization may be required.

Question 4

What about the cardiovascular benefits?

Accepted Answer

The SELECT trial showed semaglutide reduced major cardiac events (heart attack, stroke, cardiovascular death) by 20%. The REWIND trial showed similar benefits for dulaglutide. These benefits appear independent of weight loss alone.

Question 5

Can GLP-1 medications reverse my diabetes?

Accepted Answer

Some people achieve diabetes remission — defined as A1C under 6.5% without diabetes medications for at least 3 months. This is more likely in early-stage T2D with significant weight loss. It's not guaranteed, but it's a realistic goal for many.

Question 6

Is a GLP-1 better than insulin?

Accepted Answer

For many T2D patients, GLP-1 therapy achieves equal or better blood sugar control with added weight loss, lower hypoglycemia risk, and cardiovascular protection. However, advanced T2D with significant beta-cell loss may still require insulin.

GLP-1 Guide for Type 2 Diabetes (2026)

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