Mounjaro vs Wegovy: Which Is Better in 2026?
Comparing Mounjaro and Wegovy side by side — weight loss results, side effects, cost, dosing, and who should choose each.
| Category | Mounjaro | Wegovy |
|---|---|---|
| Active Ingredient | Tirzepatide | Semaglutide |
| Mechanism | Dual GIP/GLP-1 receptor agonist ✓ | GLP-1 receptor agonist |
| FDA Approved For | Type 2 diabetes | Chronic weight management |
| Administration | Once weekly injection | Once weekly injection |
| Average Weight Loss | ~21-25% of body weight ✓ | ~16-17% of body weight |
| Starting Dose | 2.5mg weekly | 0.25mg weekly |
| Maximum Dose | 15mg weekly | 2.4mg weekly |
| Dose Steps | 6 steps (2.5–15mg) | 5 steps (0.25–2.4mg) |
| A1C Reduction | ~2.0-2.4% ✓ | Not primary endpoint |
| Cardiovascular Data | SURPASS-CVOT ongoing | SELECT trial — 20% MACE reduction ✓ |
| Monthly Cost (US, no insurance) | ~$1,000-1,100 | ~$1,300-1,400 |
| Nausea Rate | ~18-30% ✓ | ~44% |
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Enzo's Tip
Two absolute powerhouses going head-to-head! Mounjaro's dual-action engine tends to win on the scale, while Wegovy has that landmark SELECT trial proving it protects hearts too. Different strokes for different folks — your insurance, your body chemistry, and your doctor's advice should guide the pick. Enzo will happily ride shotgun with either one!
Choose Mounjaro if you...
- • Have insurance that covers it
- • Want an established track record
- • Prefer a well-known medication
Choose Wegovy if you...
- • Want maximum weight loss potential
- • Have tried other GLP-1s without success
- • Your doctor recommends it
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Medical Disclaimer: Enzo is a tracking companion, not a doctor. Always consult your healthcare provider before starting, stopping, or changing any medication. The information on this page is for educational purposes only and should not be considered medical advice. Individual results may vary.